Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Have No Significant Relationship With Postoperative Arthrofibrosis After Shoulder Arthroscopy

PurposeTo determine the effect of perioperative angiotensin II receptor blocker (ARB) or angiotensin-converting enzyme inhibitors (ACEi) on postoperative arthrofibrosis, as defined by requiring manipulation under anesthesia (MUA) new diagnosis adhesive capsulitis (AC) following arthroscopic shoulder procedures.MethodsPatients were retrospectively identified using Current Procedural Terminology surgical billing codes to identify patients who underwent any procedure at a single urban academic institution from 2012 2020 with minimum 2-year follow-up. Patients excluded if <30 years old time surgery, these rarely use ARB and ACEi medications, they had pre-existing AC. Demographics, active medication prescriptions medical comorbidities recorded. Multivariable logistic regression was performed ARB/ACEi subsequent MUA AC 90 days, 1 year, 2 years.ResultsIn total, 5,559 included in final analysis. A majority cohort (53.4%) surgery between ages 50 69 years. Most male (61.8%) without obesity (67.3%). In 18.9% 15.0% taking an perioperatively, respectively. Within years’ postoperatively, 51 (0.9%) ipsilateral MUA, 174 (3.1%) developed ARBs 17.5% rate arthrofibrosis within 2-years compared 19.1% those not ARBs, although this difference significant (P = .58). Likewise, no found versus (15.0% vs 15.0%, P .99). Individual generic subgroup analysis did demonstrate associations > .05).ConclusionsARBs significantly affect arthroscopy, however female sex, diabetes mellitus, Black/African American race associated increased necessitating developing postoperatively.Level EvidenceLevel III, retrospective study. To procedures. .05). postoperatively.